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KMID : 1812020100160010077
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Journal of Neurogastroenterology and Motility
2010 Volume.16 No. 1 p.77 ~ p.82
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A Case of Cyclic Vomiting Syndrome Responding to Gonadotropin-Releasing Hormone Analogue
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Shin Young-Kook
Kwon Joong-Goo
Kim Ka-Young
Park Jae-Bum
Han Seok-Jae
Cheon Jong-Woon
Kim Eun-Young
Kim Ho-Gak
Lee Tae-Sung
Park Kyung-Sik
Won Kyoung-Sook
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Abstract
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Cyclic vomiting syndrome (CVS) is a disorder characterized by recurrent episodes of incapacitating nausea and vomiting interspersed with symptom free periods. Common triggers of cyclic vomiting include noxious stress, excitement, fatigue and menstrual period. Here, we report a case of cyclic vomiting syndrome in adult patient characterized by stereotypical vomiting attack, occurring in every menstruation period. Recurrent vomiting episodes began 6 years ago and we treated this patient with subcutaneous injection of goserelin, a gonadotropin-releasing hormone analogue (GnRHa) and oral estrogen. After 4 months of therapy, she was symptom free for the following 5 years, even with the resumed normal menstruation. Recurrence of vomiting attack with same pattern occurred 1 month before readmission. Treatment with intravenous lorazepam aborted vomiting, but could not prevent recurrences of vomiting and epigastric pain. We treated the patient with GnRHa and oral estradiol again which effectively prevented recurrence of the symptoms.
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KEYWORD
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Cyclic vomiting syndrome, Menstrual period, Gonodotropin-releasing hormone analogue
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